Indirubin-3′-oxime (IDR3O) is a synthetic derivative of indirubin used as a research reagent to modulate kinase signaling. It inhibits cyclin-dependent kinases, glycogen synthase kinase 3β, and c-Jun N-terminal kinases, and is used in biochemical, cell-based, and in vivo research. The compound is supplied as a brown to red solid with high reported purity and recommended storage conditions for powder and solutions.
- Potent inhibitor of CDKs, GSK-3β, and JNK isoforms.
- Reported enzyme IC50s in the low micromolar range for JNK1, JNK2, and JNK3.
- High reported purity suitable for biochemical and cell-based assays.
- Soluble in DMSO at high concentration; in vivo formulations documented by the supplier.
- Powder stable at -20°C for years; store solutions at -80°C for long term.